Abstract:
Antithrombic activity of Crataegus oxycantha Linn.
mother tincture was studied in adult albino mice. Paralysis
and death of an animal observed after intravenous injection
of collagen + epinephrine mixture was considered as an index of thrombosis which was later confirmed
microscopically by observing the aggregation of
disintegrated platelets along with white blood corpuscles
and red blood corpuscles in the blood capillaries of heart
and lungs tissues. On the contrary, the ability of Crataegus
oxycantha Linn. mother tincture to protect the mice from
the paralytic or lethal effect of platelet aggregating agent
was considered as an index of antithrombic activity of the
drug . The present result showed that Crataegus oxycantha
Linn. mother tincture when administered in doses of
0.05ml/mouse twice daily for three days before the
intravenous injection of collagen + epinephrine rnixture
(0.1 ml/mouse) had considerable protective effect (55.6%)
as compared to that observed in both the control groups.
