Antithrombic Activity of Crataegus Oxycantha Linn. Mother Tincture In Albino Mice

Abstract

Antithrombic activity of Crataegus oxycantha Linn. mother tincture was studied in adult albino mice. Paralysis and death of an animal observed after intravenous injection of collagen + epinephrine mixture was considered as an index of thrombosis which was later confirmed microscopically by observing the aggregation of disintegrated platelets along with white blood corpuscles and red blood corpuscles in the blood capillaries of heart and lungs tissues. On the contrary, the ability of Crataegus oxycantha Linn. mother tincture to protect the mice from the paralytic or lethal effect of platelet aggregating agent was considered as an index of antithrombic activity of the drug . The present result showed that Crataegus oxycantha Linn. mother tincture when administered in doses of 0.05ml/mouse twice daily for three days before the intravenous injection of collagen + epinephrine rnixture (0.1 ml/mouse) had considerable protective effect (55.6%) as compared to that observed in both the control groups.