Abstract:
Aim: Assessment of group‑confined likelihood ratio (GCLR) for the symptom ‘Headache’ from among 20 lesser‑known remedies clinically
verified by the Central Council for Research in Homoeopathy during the period 2012–2018. Materials and Methods: Analysis of data of
the clinical verification study, which was a multicentric, open‑label, observational clinical study conducted at 13 study sites of the council.
The 50 medicines that completed the drug proving programme of the council were clinically verified in ascending potencies of 6C, 30C and
200C. Of these, 20 lesser‑known medicines allowed analysis of the prevalence and LR of the symptom ‘Headache’. These 20 medicines
were ordered according to the prevalence of headache, and LR >1 gave an indication what medicines were more related to headache than
others. Results: The symptom ‘Headache’ was recorded in a part of the population: 4582 patients where 20 lesser‑known medicines were
prescribed. Of these medicines, 8 have a GCLR >1, indicating that the symptom headache could indicate these medicines out of the assessed
group of 20. Only 5 had statistically significant confidence interval: Allium sativum, Formicum acidum, Gymnema sylvestre, Avena sativa and
Persea americana. Among these, two medicines, Allium sativum and Formicum acidum, have significantly higher GCLR. Conclusion: Of
20 lesser‑known homeopathic medicines, two could be considered for the further evaluation of the relationship with headache. These findings
should be confirmed in properly organised prognostic factor research in a larger population, not restricted to specific medicines, that enables
proper comparison.
