Abstract:
Almost two decades ago, it was postulated that homoeopathic remedies could deliver
their benefits by interacting with the genetic blueprint. Over the years, the results of many
homeogenomic gene expression studies have confirmed this postulate. The results of
homeogenomic studies have begun to recognize which of the estimated 25,000 human
genes are targeted by different homoeopathic remedies and how the expression profiles
of these targeted genes are rearranged. From a mechanistic standpoint, seminal
homeogenomic studies have shown that homoeopathic remedies can also facilitate
epigenetic modifications such as DNA methylation. This is an important discovery
because DNA methylation plays an important role in the control of the expression of
many genes. Understanding of the genes targeted by different homoeopathic remedies,
taken together with information about the function of the protein/s encoded by the
targeted gene/s provides a further complementary approach to homoeopathic remedy
selection. In this review, as an example, we show how the results of homeogenomic
studies support the applicability of frequently used homoeopathic remedies in patients
suffering from cancer, particularly with respect to upregulation of the gene TP53. This
review also outlines how the results of homeogenomic studies may also provide further
help with potency selection and optimum dosage regimen.
