Abstract:
Introduction: Identifying the need for strengthening of the immune system, the
investigator has developed new Human Immunodeficiency Virus (HIV) nosode and
evaluated its effect on HIV positive individuals through a clinical trial.
Methods: Standardized and the scientific method of HIV nosode preparation has been
described and documented. Thirty‑seven HIV‑infected persons were registered for the
trial, and ten participants were dropped out from the study, so the effect of HIV nosode
30C and 50C, was concluded on 27 participants under the trial.
Results: Out of 27 participants, 7 (25.93%) showed a sustained reduction in the
viral load from 12 to 24 weeks. Similarly 9 participants (33.33%) showed an increase
in the CD4+ count by 20% altogether in 12th and 24th week. Significant weight gain
was observed at week 12 (P = 0.0206). 63% and 55% showed an overall increase in
either appetite or weight. The viral load increased from baseline to 24 week through
12 week in which the increase was not statistically significant (P > 0.05). 52% (14
of 27) participants have shown either stability or improvement in CD4% at the end
of 24 weeks, of which 37% participants have shown improvement (1.54‑48.35%) in
CD4+ count and 15% had stable CD4+ percentage count until week 24 week. 16 out
of 27 participants had a decrease (1.8–46.43%) in CD8 count. None of the adverse
events led to discontinuation of study.
Conclusion: The study results revealed improvement in immunological parameters,
treatment satisfaction, reported by an increase in weight, relief in symptoms, and an
improvement in health status, which opens up possibilities for future studies.
