Abstract:
Objective: Cerebral ischaemia is the third leading cause of death after cancer and
myocardial infarction. The protective effect of some homoeopathic drugs has been
studied in the Middle Cerebral Artery Occlusion (MCAO) model of rat.
Materials and Methods: The rats were pretreated with 200C potency once daily for 5
days orally (1 drop or 21 μl) and post treated after 24 hr of MCAO with 30C potency three
times a day for 5 days orally (1 drop or 21 μl) with homoeopathic medicines Crotalus,
Phosphorus, Arnica and Crocus.
Results: The content of antioxidants, Thiobarbituric Acid Reactive Substances (TBARS)
was elevated significantly whereas the level of Glutathione (GSH) was depleted
significantly in the MCAO of rats as compared to the sham group. The activities of
antioxidant enzymes, Glutathione Peroxidase (GPx), Glutathione Reductase (GR) and
Glutathione-S-Transferase were decreased significantly in MCAO group as compared
to sham group. The medicines used on rats (pre and post treated in potencies of 200C
and 30C respectively) have protected the activities of these enzymes significantly
when compared with the animals of MCAO group.
Conclusion: The study has shown that the homoeopathic drugs have protected most
of the studied parameters significantly but further studies are required to comment on
the mechanism and reproducibility of homoeopathic drugs.
