Abstract:
Background and Aim: The drug Fucus vesiculosus is used in alternative system of
medicine and homoeopathy, for the treatment of obesity. But in homoeopathic literature
survey, we found no substantial pharmacological evidence to prove its safety and
efficacy. So, the study was taken up on this drug and evaluated it on different animal
models (diet‑induced and chemical‑induced models) of obesity.
Material and Methods: Obesity was induced in adult female Wistar albino rats
(100-120 g) by feeding the rats with cafeteria diet for 42 days in diet‑induced model and
by administration of single intraperitoneal injection of Triton X‑100 in chemical‑induced
model. In the diet‑induced model, weight of the animals was measured every week and
parameters like total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL),
very low density lipoprotein (VLDL) and high density lipoprotein (HDL) were measured
on 0, 21 and 43 days. Further, locomotor activity was assessed for all the animals on
43rd day. On the same day, the rats were sacrificed by cervical dislocation and their
organ and fat pad weights were recorded. In the chemical‑induced model, the above
parameters were assessed on day 0 and day 8.
Results: Feeding cafeteria diet for 42 days resulted in significant increases in the
body weight, TC, TG, LDL and VLDL levels and a reduction in the HDL level. Further,
the locomotor activity was found to be reduced significantly. Treatment with Fucus
vesiculosus significantly protected the cafeteria diet fed animals from all these changes
and helped to maintain normal locomotor activity. Similar results were observed in
chemical‑induced obesity model also.
Conclusion: Fucus vesiculosus treatment prevented the rats from becoming obese
and the biochemical and physical parameters were maintained to normal levels. So, the drug Fucus vesiculosus can be taken up for further research on human subjects.
