Abstract:
Objective: To elicit the pathogenetic response of the drug Andrographis paniculata in homoeopathic
potencies on healthy human beings.
Methodology: Drug Andrographis paniculata was proved by the Central Council for Research in
Homoeopathy through double-blind, randomized, placebo-controlled method. The study was
conducted at three centers. The drug was proved in two potencies (6C and 30C) on 39 apparently
healthy volunteers who were selected after conducting pre-trial medical examination by the medical
specialists and routine laboratory investigations. In the first phase volunteers were given 56 doses
(04 doses per day for 14 days) of placebo. In the next two phases 56 doses (04 doses per day for
14 days) of each potency or placebo were consumed. The symptoms generated during the trial
period were noted by the volunteers and elaborated by the Proving Masters. The data obtained
from all the three centers was compiled at proving-cum-data processing cell at CCRH headquarters
after de-coding.
Observations: Out of the 23 provers who were on actual drug trial, 06 manifested symptoms. Drug
was able to produce symptoms in both the potencies more or less related to every part of the body.
Some of the symptoms have been reproved which are mentioned in different literatures after the
fragmentary proving.
Conclusion: New and reproved pathogenetic responses elicited during the proving trial expands
the scope of use of the drug Andrographis paniculata and will benefit the research scholars and
clinicians. These symptoms will carry more value when verified clinically.