Abstract:
Dynamised and Undynamised preparations of Alloxan 6x, 30x, 200x, and 1000x were
examined for its anti-diabetic activities in Alloxan induced diabetes mellitus albino rats.
Oral administration of dynamised potencies of Alloxan 6x, 30x, 200x, and 1000x at dose
level of 50μ1/100 g.b.w. daily for 30 days regularly exhibited slow and steady fall in blood
sugar level accompanied with perceptible increase in serum growth hormone (GH) i.e. p
< 0.01 (less significant) and p < 0.001 (significant) respectively when compared to
dynamised and Undynamised control as well as Undynamised Alloxan fed groups under
identical conditions. Histological and histo-morphometric studies also revealed
reactivation of Pancreatic β-cells. Dynamised dilutions of Alloxan acts steadily through
hypothalamo-hypophysial- pancreatic β-cells axis producing selective reactivation of β-
cells at micro-doses, steadily viz 6x < 30x < 200x < 1000x. The drug may indirectly release
Releasing factors (RF) from hypothalamic neurons, stimulating the secretion of growth
hormone which in turn triggers optimum insulin secretion from β-cells. The therapeutic
action of the test drug in dynamised dilutions at micro dose and relatively high dilutions
on pancreatic β-cells confirms the phenomenon of “Potentization” & “Similia Similibus
Curentur” and lack of acute and sub-acute toxicity at fairly large dosage may open up
new prospects in the treatment of diabetes mellitus and throw light in elucidating the
mechanism of action at higher dilutions. It was noticed that the dynamised dilutions of
alcohol fed control group is more toxic and lethal to animals than the dynamised and
Undynamised dilutions of Alloxan and Undynamised alcohol fed control groups.
Furthermore, it was also discernible that blood sugar and growth hormone levels were
stabilized even after withdrawal of test drug in its 30x, 200x and 1000x potencies.
