Abstract:
Objective: Objective of the study was to elicit the pharmacodynamic response of the drug Paraffin
on healthy human volunteers in non-toxic doses.
Methodology: Drug was proved through a double-blind method and multi-centric study. Trial drug
was proved in three potencies (6C, 30C and 200C) on 43 volunteers who were declared apparently
healthy during their pre-trial medical examination by medical specialists. The volunteers consumed
56 doses (four doses per day for fourteen days) of each potency (6C, 30C and 200C) in three stages
for a varying period. The symptoms generated during the trial period were noted by the volunteers
and elaborated and cross examined by the Proving Masters. The data obtained from different centers
were compiled at proving-cum-data processing cell at CCRH headquarters after de-coding.
Observation: Out of the 30 provers who were on actual drug trial, 13 manifested symptoms. Drug
was able to produce symptoms in each potency more or less on every part of the body. Only a few
symptoms appeared in more than one prover. Some of the symptoms have been reproved which
are mentioned in the fragmentary provings published in different literature.
Conclusion: Pharmacodynamic response is elicited from every part of the body. Symptoms appeared
(new and reproved) during the proving trial will add to the literature available on the drug and
benefit the research scholars and clinicians. The symptoms need to be verified through clinical
application in different clinical conditions.
