dc.description.abstract |
Objective: The primary objective was to evaluate the effects of homoeopathic
medicines in fifty millesimal (LM) potencies vis‑à‑vis centesimal (CH) potencies on
symptomatic uterine fibroids.
Materials and Methods: A multicentric randomized clinical trial was conducted at
six centers under the Central Council for Research in Homoeopathy. Patients were
screened for symptomatic uterine fibroids with the preset inclusion and exclusion criteria.
A consultant specialized in obstetrics and gynecology was engaged at each center
to screen and follow‑up the enrolled patients. Homoeopathic physicians engaged in
the study were responsible for prescription and follow up for 12 months. The primary
outcome was changes in symptoms of uterine fibroid on a visual analog scale (VAS) of
0–10 and findings through ultrasonography (USG) between LM and CH potencies. The
secondary outcome was to assess the changes in uterine fibroid symptom quality of life
questionnaire (UFSQOL). Data analysis was done as per intention to treat (ITT) analysis.
Results: Of 216 patients enrolled in the study (LM: 108 and CH: 108), 209 patients were
analyzed under modified ITT (LM: 106, CH: 103). Both LM and CH potencies were equally
effective in reducing the symptoms (percentage change) due to uterine fibroid on VAS scale
after 1 year of treatment (P > 0.05). The health‑related quality of life (HRQOL) and subdomains
of UFSQOL also showed equal effectiveness in both the groups (P = 0.05). However, no
difference was observed in all the USG findings except for uterine volume (P = 0.03). There
was overall difference before and after homoeopathic treatment irrespective of assigned
groups, i.e., LM or CH (P < 0.05) in all the above parameters. The medicines frequently prescribed were: Pulsatilla, Sulphur, Lycopodium, Sepia, Phosphorus, Calcarea carbonica, and Natrum muriaticum. Conclusion: LM and CH potencies are equally effective in giving symptomatic relief to patients suffering from
symptomatic uterine fibroids. |
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