Abstract:
Background: Chronic rhinosinusitis (CRS) is one of the most common illnesses interfering
with patient’s quality of life and work. Observational studies conducted by the Council
indicate positive outcome. This protocol has been developed to ascertain the usefulness of
homoeopathic intervention in comparison with control group in a randomised control setting.
Objectives: Primary objective is to evaluate the changes in TSS (Total Symptoms
Score) and SNOT‑22 (Sino‑nasal Outcome Test‑22) within the two groups of the study
(Homoeopathy + Placebo). Secondary objective is to evaluate changes in SNOT‑22 at
end of the trial, changes in Lund and Mackay staging of CT scan, rhinoscopy grading,
absolute eosinophil count, global assessment by investigator and patient, and number
of acute exacerbations of CRS (for frequency, duration and intensity) as per TSS scale
compared to placebo.
Methods/Design: This is a randomised double blind, placebo‑controlled, multi‑centric
parallel arm trial of 6 months (three months treatment and three months observation
period) with 14 days run‑in period. The primary outcome is a composite of the changes
in the TSS and SNOT‑22 over 3 months from baseline with area under the curve and
changes over 3 months in the Sinus Nasal Outcome Test 22 (SNOT‑22) from baseline.
Prescription shall be made as per the homoeopathic principles. Efficacy data will be
analysed in the intention‑to‑treat population.
Discussion: This trial will help to evaluate the efficacy of homoeopathic individualised
treatment using LM‑potencies versus placebo in patients suffering from CRS as per the
homoeopathic dictum.
