dc.description.abstract |
Background: A double‑blind, randomized, placebo‑controlled Homoeopathic
Pathogenetic Trial (HPT/Drug Proving) of Hydroquinone was conducted, using the
accepted guidelines, ethical approval and scientific documentation The potentization
method was standardized. Toward enhancing the quality of HPT, the investigator
proposed and evaluated the data using the Quantitative Pathogenetic Index and
Qualitative Pathogenetic Index. Usable symptoms were derived from the study. The
medicine was suggested for the treatment of vitiligo, based on its known toxicological
effects.
HPT of a new medicinal substance, using the established parameters, to evaluate
symptoms in healthy volunteers was carried out using a controlled experiment.
Aims: The aim of the study was to conduct a HPT using the accepted and scientific
guidelines to derive clinically usable symptoms.
Material and Methods: A double‑blind, randomized, placebo‑controlled homoeopathic
pathogenetic trial was conducted in 22 volunteers (provers), out of whom 15 received
Hydroquinone in 30C potency, thrice daily, for four weeks, while seven received the
placebo. The volunteer’s symptoms during the initial seven days of the run‑in period
were carefully noted, and these were used as a filter, by elimination of the same
symptoms in that volunteer during the verum phase. Thorough documentation such as
Informed Consent Form, approval by the Ethics Committee, laboratory investigations,
and safety and ethical measures, were taken care of. The volunteers were trained to
write data in the prescribed diaries which was analyzed at the end. The investigator
introduced Quantitative and Qualitative Pathogenetic Indices as parameters in the
evaluation of the data derived from the HPT.
Results: The HPT of Hydroquinone exhibited qualitatively distinct symptoms, which
could be applied in clinical practice. Safe use was documented. An anecdotal study
supported the proposed efficacy of Hydroquinone for the treatment of vitiligo and further exploration could be carried out.
Conclusion: The HPT of Hydroquinone brought in qualitative symptoms. It was noted
that a potentized preparation could produce many functional symptoms, but could not
produce degenerative pathological symptoms such as vitiligo. The preparation could
be used by the profession for vitiligo on the basis of its toxicological effects, supported
by the anecdotal study. The Quantitative and Qualitative Pathogenetic Indices could
further be used in future HPTs as a tool. |
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