Alterations of Cytogenetical Effects By The Oral Administration of A Homoeopathic Drug, Ruta Graveolens, In Mice Exposed To Sub-Lethal X-Irradiation

Abstract

The 30th and 200th potencies of the homoeopathic drug, Ruta Graveolens, commonly used in treatment of bone injuries, have been tested for their possible radio – protective action, using several protocols like bone marrow chromosome aberration, micronuclei testing (MNT) and sperm – head anomaly, against sub – lethal x-irradiation at 100 rad and 200 rad doses in the Swiss albino mice, Mus muscles at four different fixation intervals, viz., 24 hr, 48 hr, 72 hr and 96 hr maintaining suitable controls. While the frequencies of chromosome aberrations, micronucleated cells and abnormal sperm- heads were found to be appreciably decreased in all the fixation intervals in the Ruto-30 and Ruta-200 fed mice in both the 100 rad and 200 rad treated series when compared to their respective controls, interestingly enough, an apparent increase in the mitotic index was noted at all the intervals in the Ruta-30 as well as Ruta-200 fed series.