A study of the effect of mother tincture of Syzygium jambolanum on metabolic disorders of Streptozotocin induced diabetic male albino rat

Abstract

Background: Syzygium jambolanum is widely used in Homoeopathy for treating Diabetes mellitus and its complications. Objective: To explore the remedial effects of homoeopathic mother tincture Syzygium jambolanum on metabolic disorders of Streptozotocin induced diabetic male albino rat. Materials and Methods: Serum levels of insulin, urea, uric acid, creatinine, albumin and total protein were measured as per the standard methods using specific kits. Amount of glycogen in liver and skeletal muscles, activities of antioxidant enzymes as well as content of free radical bye products in liver and kidney tissues were assessed biochemically following the standard protocol. Results: The study indicated that the treatment of mother tincture of Syzygium jambolanum in diabetic albino rats restored the body weight and significantly controlled the elevated blood glucose level as compared with the untreated group. Levels of glycogen in liver and skeletal muscle tissues were recovered by treatment with Syzygium jambolanum in diabetic rats as compared with the untreated diabetic rats. Levels of serum urea, uric acid and creatinine were increased in diabetic rats significantly as compared with the control group, which were resettled in the control group after treatment with mother tincture of Syzygium jambolanum in diabetic animals. Alongside, significant recovery in the activities of antioxidant enzymes like catalyse, peroxidase and super oxide dismutase, the levels of free radicals generated as bye products in hepatic and renal tissues were also observed in the treatment with mother tincture of Syzygium jambolanum treated diabetic animals with respect to the untreated in diabetic animals. Conclusion: The homoeopathic mother tincture of Syzygium jambolanum has therapeutic effect on metabolic disorders and oxidative injuries in Streptozotocin induced diabetic male albino rats.